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Osteoporosis Imprimer
Exposure to Oral Bisphosphonates and Risk of Esophageal Cancer
Cardwell et al (JAMA. 2010;304(6):657-663. doi:10.1001/jama.2010.1098) investigated whether there is an association between bisphosphonate use and esophageal cancer. Data were extracted from the UK General Practice Research Database to compare the incidence of esophageal and gastric cancer in a cohort of patients treated with oral bisphosphonates between January 1996 and December 2006 with incidence in a control cohort. Cancers were identified from relevant Read/Oxford Medical Information System codes in the patient's clinical files. Cox proportional hazards modeling was used to calculate hazard ratios and 95% confidence intervals for risk of esophageal and gastric cancer in bisphosphonate users compared with nonusers, with adjustment for potential confounders. Mean follow-up time was 4.5 and 4.4 years in the bisphosphonate and control cohorts, respectively. Excluding patients with less than 6 months' follow-up, there were 41 826 members in each cohort; 79 esophageal cancers occurred in the bisphosphonate cohort and 72 esophageal in the control cohort. The incidence of esophageal and gastric cancer combined was 0.7/1000 person-years of risk in both the bisphosphonate and control cohorts; (esophageal cancer alone 0.48 and 0.44 /1000 person-years of risk, respectively). There was no difference in risk of esophageal and gastric cancer combined between the cohorts for any bisphosphonate use. There also was no difference in risk of esophageal or gastric cancer by duration of bisphosphonate intake.


SHARING-OBGYN is a service that I intend to share with you. The idea is to send one short email message a day concerning an article that appeared recently and might be of interest to you.
The selection of the articles is arbitrary, but there are no commercial interests involved and no conflict of interest.
If you want to be removed from the list of persons to whom these emails are sent please let me know.
If you want to bring comments or add email addresses of friends or colleagues, please feel free to do so.


Next Meeting Belgian Menopause Society -
Octobre 2th 2010:
"The Menopause Mythology : having sex after fifty : Men love their drug, are women still waiting for theirs?"


November 13th 2010 will be
"Update in Postmenopausal Osteoporosis"

 
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