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POI - No. 688 Imprimer
Schmidt et al J Clin Endocrinol Metab. 2010 Nov 3. [Epub ahead of print] characterized the prevalence of psychiatric disorders and the timing of onset of clinically significant depression relative to both the diagnosis of primary ovarian insufficiency (POI) and the onset of menstrual irregularity in women with POI. They conducted a cross-sectional clinic-based study: A total of 174 women with spontaneous 46, XX POI and 100 women with Turner syndrome participated in the study. Lifetime histories of depression in POI exceeded rates of depression reported in women with Turner syndrome and community-based samples of women (P < 0.001). The onset of depression frequently preceded the diagnosis of POI but occurred after the onset of menstrual irregularity. Analyses standardizing the periods of risk for depression showed that similar numbers of depressions occurred before and after these events. The authors concluded that POI is associated with an increased lifetime risk for major depression. Attention to the presence of depression in POI should become an important part of the care for these women. The onset of depression frequently occurs after signs of altered ovarian function but before the diagnosis of POI. Thus, in some women the association between POI and depression suggests an overlapping pathophysiology rather than a causal relationship
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