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Breast Cancer - No. 709 Imprimer
Effect of the Gonadotropin-Releasing Hormone Analogue Triptorelin on the Occurrence of Chemotherapy-Induced Early Menopause in Premenopausal Women With Breast Cancer : a RCT.
Lucia Del Mastro, et al (JAMA. 2011;306(3):269-276. doi: 10.1001/jama.2011.991 determined the effect of the temporary ovarian suppression obtained by administering the gonadotropin-releasing hormone analogue triptorelin during chemotherapy on the incidence of early menopause in young patients with breast cancer undergoing adjuvant or neoadjuvant chemotherapy. They enrolled 281 premenopausal women with stage I through III breast cancer who were candidates for adjuvant or neoadjuvant chemotherapy. Twelve months after the last cycle of chemotherapy, the rate of early menopause was 25.9% in the chemotherapy-alone group and 8.9% in the chemotherapy plus triptorelin group, an absolute difference of −17% (95% confidence interval, −26% to −7.9%; P < .001). The odds ratio for treatment-related early menopause was 0.28 (95% confidence interval, 0.14 to 0.59; P < .001).
 
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